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Preparation of tritium labelled estetrol [estra‐1,3,5(10)‐ triene‐3,15α,16α,17β‐ tetrol 6,7‐ 3 H]
Author(s) -
Fishman Jack,
Guzik Henry
Publication year - 1970
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590060406
Subject(s) - tritium , chemistry , hydrolysis , derivative (finance) , radiochemistry , nuclear chemistry , metabolite , ketone , medicinal chemistry , organic chemistry , physics , nuclear physics , financial economics , economics , biochemistry
The preparation of the tritium labelled fetal metabolite estra‐1, 3, 5 (10)‐3, 15α, 16α, 17β‐tetrol 6,7‐ 3 H is described. The material was prepared by oxidation of the tetrol tetraacetate lb to the 6‐keto derivative II. Reduction of the 6‐ketone to the 6‐hydroxy compound III and dehydration with dimethylsulfoxide gave the Δ6 derivative III. Reduction of III with tritium followed by hydrolysis gave the tetrol‐ 3 H with a specific activity of 43 curies/mmole.