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A study of the stability and radiochemical purity of some radiopharmaceuticals. 2. Labelled chlormerodrin
Author(s) -
Buriánek J.,
Cífka J.
Publication year - 1970
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590060303
Subject(s) - thermal decomposition , decomposition , chemistry , radiochemistry , nuclear chemistry , organic chemistry
The chromatographic behaviour of chlormerodrin and its radiochemical impurities was studied in various solvents. The main product of thermal decomposition of chlormerodrin was identified as 3‐chloromercuri‐2‐hydroxypropylurea. The thermal decomposition of chlormerodrin is accelerated by the presence of theophylline and suppressed by sodium chloride. The main product of radiation decomposition of chlormerodrin is inorganic mercury. The yield of radiation decomposition was studied as a function of the concentration of chlormerodrin. The radiation decomposition of chlormerodrin is not essentially influenced by the presence of some other substances, however these substances can under certain circumstances support the formation of 3‐chloromercuri‐2‐hydroxypropylurea as the product of the radiolysis.