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Carbon‐14 and tritium labelling of m ‐(1‐methyl‐3‐propyl‐pyrrolidinyl)‐ phenol monohydrochloride (profadol; CI‐572)
Author(s) -
Blackburn C. E.
Publication year - 1970
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590060104
Subject(s) - tritium , phenol , labelling , chemistry , moiety , acetic acid , pyrrolidine , aqueous solution , carbon 14 , carbon fibers , catalysis , platinum , nuclear chemistry , organic chemistry , radiochemistry , materials science , composite number , biochemistry , physics , quantum mechanics , nuclear physics , composite material
Carbon‐14 and tritium labelled preparations of m‐(1‐methyl‐3‐propyl‐3‐pyrrolidinyl)‐phenol monohydrochloride (CI‐572) are described. CI‐572‐ 14 C, with the carbon‐14 label in the C‐2 position of the pyrrolidine moiety, was synthesized in five steps from K 14 CN. CI‐572‐ 3 H was prepared by heterogeneous platinum‐catalyzed exchange with tritiated water in acetic acid. Characterization of CI‐572‐ 3 H included an evaluation of the tritium label stability in water and in aqueous acidic and basic media.