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Some factors involved in the decomposition of labeled steroids during storage
Author(s) -
Geller Lawrence E.,
Silberman Norman
Publication year - 1969
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590050110
Subject(s) - decomposition , chemistry , estrone , benzene , solvent , crystallization , chromatography , organic chemistry , biochemistry , hormone
Estrone,6‐7‐ 3 H in benzene has been found to exhibit greater decomposition when stored at −5 °C than when stored at +5 °C. The reason is attributed to lack of uniform dispersal of the solute due to solvent crystallization. The non‐distillable residues from commercial solvents have been found to cause rapid destruction of a stored radiochemical if not removed before storage. Data is presented which indicates that the best method for reducing the total amount of decomposition of labeled steroids which are stored for extended periods of time is repurification at regular time intervals.