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Tritium labelling of 2‐(O‐chlorophenyl)‐2‐(methylamino)‐Cyclohexanone (ketamine; CI‐581) by acid catalyzed exchange: An example of intramolecular competition for tritium between substituted aromatic and cyclohexanone rings
Author(s) -
Blackburn C. E.,
Ober R. E.
Publication year - 1967
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590030106
Subject(s) - cyclohexanone , chemistry , tritium , intramolecular force , ring (chemistry) , catalysis , labelling , medicinal chemistry , organic chemistry , biochemistry , physics , nuclear physics
The preparation and characterization of tritium‐labelled 2‐(o‐chlorophenyl)‐2‐(methylamino) cyclohexanone hydrochloride is described. Under the exchange conditions employed (CF 3 COOH, 10 c 3 H 2 O, Pt), it was expected that the tritium would be distributed between the phenyl and cyclohexanone rings. Our observations indicated that the major portion of the tritium was located in the cyclohexanone ring.