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Improvement of the method of synthesis of δ‐Aminolevulinic acid‐4‐ 14 C hydrochloride
Author(s) -
Mitta A. E. A.,
Ferramola A. M.,
Sancovich H. A.,
Grinstein M.
Publication year - 1967
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590030104
Subject(s) - phthalimide , phthalic anhydride , hydrochloride , yield (engineering) , condensation , chemistry , phthalic acid , glycine , organic chemistry , nuclear chemistry , materials science , catalysis , amino acid , physics , biochemistry , metallurgy , thermodynamics
δ‐aminolevulinic acid‐4‐ 14 C was built up from phthalimide using K 14 CN as the radioactive starting material. This method avoids the less practical synthesis via glycine‐ 14 C and its condensation with phthalic anhydride to afford phthalylglycine‐1‐ 14 C whose yield, based on K 14 CN, is thus considerably improved.