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Synthesis and enzymatic resolution of DL‐2‐phenylglycine‐1‐ 14 C
Author(s) -
Billings Ruth,
Sullivan Hugh R.
Publication year - 1967
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590030103
Subject(s) - chemistry , yield (engineering) , hydrolysis , stereoselectivity , strecker amino acid synthesis , derivative (finance) , enzymatic hydrolysis , resolution (logic) , enzyme , stereochemistry , organic chemistry , catalysis , enantioselective synthesis , materials science , artificial intelligence , computer science , economics , financial economics , metallurgy
DL‐2‐Phenylglycine‐1‐ 14 C was prepared in good yield employing a modified Strecker synthesis. The resolution of DL‐2‐phenylglycine into its pure enantiomorphs was accomplished by the stereoselective enzymatic hydrolysis of the N‐chloroacetyl derivative of the L‐optical isomer using hog kidney acylase.