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Preparation of bis‐/2‐chloroethyl‐1,2‐ 3 H/methylamine hydrochloride
Author(s) -
Filip J.
Publication year - 1966
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590020308
Subject(s) - methylamine , acetylene , hydrochloride , ethylene , chemistry , hydrochloric acid , medicinal chemistry , nuclear chemistry , chloride , organic chemistry , catalysis
Abstract Bis‐(2‐chloroethyl‐1,2‐ 3 H) methylamine hydrochloride was prepared. The starting product was acetylene‐1,2‐ 3 H which was selectively hydrogenated to ethylene‐1,2‐ 3 H. It was observed that on reduction with chromium (II) chloride solution in dilute hydrochloric acid the isotopic exchange with acetylene‐1,2‐ 3 H is negligible. Ethylene was converted to ethyleneoxide‐1,2‐ 3 H by the usual method. Ethyleneoxide‐1,2‐ 3 H can be used for synthesis of several labelled halogenalkylamines and as the starting compound for other syntheses.