Premium
Synthesis of L‐ascorbic‐4‐ 3 H acid
Author(s) -
Bell E. M.,
Baker E. M.,
Tolbert B. M.
Publication year - 1966
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590020203
Subject(s) - ascorbic acid , chemistry , carbanion , isomerization , carbon fibers , nuclear chemistry , inorganic chemistry , organic chemistry , medicinal chemistry , catalysis , food science , materials science , composite number , composite material
A method is presented for preparation of L‐xyloascorbic‐4‐ 3 H acid 9.5μC/mg by the exchange of 8 M dipotassium ascorbate in tritiumlabeled water by heating 20 hours at 100°C The data confirms the assumptions of Brenner ( 8 ), that alkaline isomerization of ascorbic acid proceeds through a carbanion on carbon‐4. A study of the radiation stability of crystalline ascorbic acid indicates that it is not unusually radiation sensitive.