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Synthesis of 2, 4, 7‐triamino‐6‐phenylpteridine (triamterene) labelled with tritium or carbon‐14
Author(s) -
Blackburn D.,
Burghard G.
Publication year - 1966
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590020106
Subject(s) - triamterene , chemistry , toluene , tritium , yield (engineering) , reagent , nuclear chemistry , carbon 14 , carbon fibers , organic chemistry , radiochemistry , medicinal chemistry , materials science , medicine , physics , composite material , quantum mechanics , composite number , blood pressure , nuclear physics , metallurgy , hydrochlorothiazide , radiology
The diuretic drug triamterene was labelled with carbon‐14 by condensing the intermediate phenylacetonitrile‐1‐ 14 C with 2,4,6‐triamino‐5‐nitrosopyrimidine. The tritiated triamterene was prepared by direct synthesis from toluene‐3,4‐ 3 H 1/2 and toluene‐3‐ 3 H. The 3 H‐toluenes were prepared in excellent radiochemical yield by hydrolyzing the dry Grignard reagent of the appropriate bromotoluene with tritium oxide.