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The synthesis and isotopic analysis of CH 3 18 OH and CH 3 17 OH
Author(s) -
Borowitz J. L.,
Raviv A.,
Rona P.,
Sadeh D.,
Samuel D.,
Klein F. S.
Publication year - 1965
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590010402
Subject(s) - methanol , chemistry , hydrolysis , carbon monoxide , pyrolysis , palladium , hydrogen , ethanol , trimethyl phosphate , phosphate , mass spectrometry , oxygen , nuclear chemistry , oxygen 18 , radiochemistry , inorganic chemistry , catalysis , isotopes of oxygen , organic chemistry , chromatography
A number of methods of synthesis of methanol labelled with 18 O or with 17 O have been evaluated. The best method is considered to be the partial hydrolysis of trimethyl phosphate. Ethanol‐ 18 O can be prepared analogously by the partial hydrolysis of triethyl phosphate. The most accurate method for the isotopic analysis of oxygen in methanol is by pyrolysis in a specially designed vessel, the hydrogen being extracted through a palladium tube and the residual carbon monoxide analysed mass‐spectrometrically.