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A simple and improved method for [ 11 C]phosgene production with iron(III) oxide
Author(s) -
Kuge Y.,
Nishijima K.,
Seki K.,
Ohkura K.,
Tsukamoto E.,
Nagatsu K.,
Tanaka A.,
Tamaki N.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401361
Subject(s) - chemistry , oxidizing agent , phosgene , nuclear chemistry , catalysis , oxide , iron oxide , granule (geology) , inorganic chemistry , radiochemistry , organic chemistry , geology , geomorphology
[ 11 C]COCl 2 is a precursor for several useful radiopharmaceuticals. [ 11 C]COCl 2 is generally produced by catalytic oxidation of [ 11 C]CCl 4 produced from [ 11 C]CH 4 . In order to develop a simplified method for [ 11 C]COCl 2 production; we examined effects of oxidizing agents (Fe 2 O 3 , CuO) on the [ 11 C]COCl 2 yields. The yields of [ 11 C]COCl 2 , assessed by the yields of [ 11 C]diphenylurea, was increased by using Fe 2 O 3 powder mixed with iron granule, compared with those by Fe alone or CuO alone. Yields of [ 11 C]CGP‐12177 were also significantly higher with Fe 2 O 3 than without Fe 2 O 3 . The present results show that Fe 2 O 3 mixed with iron granule improve the conversion of [ 11 C]CCl 4 to [ 11 C]COCl 2 and the yields of [ 11 C]CGP‐12177. Thus, we have developed a simple and improved method for [ 11 C]COCl 2 production with iron oxide (Fe 2 O 3 ).