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An improved synthesis of 3′‐DEOXY‐3′‐[ 18 F]fluorothymidine ([ 18 F]FLT) and the fate of the precursor, 2, 3′‐anhydro‐5′‐ O ‐(4, 4′‐dimethoxytrityl)‐thymidine
Author(s) -
Cleij M. C.,
Steel C. J.,
Brady F.,
Ell P. J.,
Pike V. W.,
Luthra S. K.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401306
Subject(s) - chemistry , yield (engineering) , radiochemistry , chemical synthesis , base (topology) , stereochemistry , in vitro , biochemistry , mathematical analysis , materials science , mathematics , metallurgy
Summary The fate of the precursor, 2, 3′‐anhydro‐5′‐ O ‐(4, 4′‐dimethoxytrityl)‐thymidine was investigated during the synthesis of [ 18 F]FLT with the aim of improving the radiochemical yield. This precursor was shown to undergo a rapid base catalysed elimination reaction and to be consumed within 5–10 min. The by‐product was identified. Modification of the synthesis has produced between 1.85–3.70 GBq (50–100 mCi) of [ 18 F]FLT in 60 min using an automated synthesis system.