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Drug interactions in radiopharmacy: A first mathematical approach
Author(s) -
Avila A. S.,
Bezerra R.,
Mattos D. M.,
BernardoFilho M.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401291
Subject(s) - chemistry , drug , mechanism of action , in vitro , biological system , mechanism (biology) , pharmacology , compartment (ship) , biochemistry , medicine , oceanography , philosophy , epistemology , biology , geology
The action of cyclophosphamide (CP) on the binding of the 99mTc‐MDP on plasma (P) and blood cells (BC) isolated from blood withdrawn from Wistar rats, using an in vitro model was evaluated. The experimental measures were studied starting with the parameter estimation of regressive trend lines, analysis of variance and residuals and a closed two compartment system were analyzed. In the presence of CP, the curves crossed each other at 48 h, but diverged without the drug. The short‐term components of the two‐compartment system converged in 1 hour. The mathematical approach to analyze the drug interactions mechanism with the studied radiopharmaceutical is in agreement with the known biological phenomena. In spite of the results, it is necessary to consider new procedures to define the behaviors of the interactions.