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Production of 103 Pd by proton irradiation of silver
Author(s) -
Mausner L. F.,
Kolsky K. L.,
Awasthi V.,
Srivastava S. C.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401273
Subject(s) - chemistry , radiochemistry , irradiation , proton , isotope , nuclear chemistry , nuclear physics , physics
Brachytherapy with 103 Pd (t 1/2 = 16.97 d) has shown significant success in treating prostate cancer. We have investigated a new high‐energy accelerator route with the Ag(p, 2pxn) 103 Pd reaction. Natural Ag foils were irradiated at energies from 75 to 140 MeV at the Brookhaven Linac Isotope Producer (BLIP). Radiochemical separation of Pd from the Ag target utilized chromatography with Chelex‐100 TM . A thick target (0.63cm) irradiation at 140 MeV, (45_A current, 24d) produced 751GBq of 103 Pd and 259 GBq of 100 Pd at EOB and useful quantities of 95m Tc (3.3 GBq) and 97 Ru (377 GBq). A 20d decay time is required to reduce the 100 Pd (t 1/2 = 3.6 d) and its daughter 100 Rh (t 1/2 = 20.8h) to less than 2%. The radiochemical process gave a Pd chemical recovery of ∼99%, specific activity at EOB 514MBq/_g, but some Rh isotope remained. Practical production of 850 GBq per run will be possible with thick targets.