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Effect of increased temperature on labelling efficiency of some 99m Tc‐radiopharmaceuticals
Author(s) -
Maksin T.,
Djokić D.,
Janković D.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401225
Subject(s) - chemistry , labelling , pertechnetate , pyrophosphate , colloid , radiochemistry , technetium , acetone , chromatography , methanol , high performance liquid chromatography , impurity , nuclear chemistry , enzyme , biochemistry , organic chemistry
The influence of increased temperature on the labelling efficiency with 99m Tc for some compounds: pyrophosphate (PyP), dicarboxypropane diphosphonate (DPD), dimercaptosuccinate (DMS) and Sn‐colloid was investigated. The samples were exposed at 37°C for different time intervals and after that each of them was labelled with 99m Tc (pertechnetate were simply injected into vials with samples). The radiochemical analyses were performed by paper and TL chromatography using different chromatography papers (Whatman N°1, SG, Schleicher&Schull) and proper mobile phases (80% methanol, 1N NaCl, acetone). Those results indicate the increases of impurity in the case of 99m Tc‐PyP. In the case of 99m Tc‐DPD and 99m Tc‐DMS unsuitable complexes for bone and kidney image respectively were formed. There were no changes in results of quality control for 99m Tc‐Sn colloid. Therefore it is very important for producer and also user of Tc‐radiopharmaceuticals to know the possible effect of bed storage and transportation condition on their quality.