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Preparation and experimental study of a new renal imaging agent: N, N‐BIS (2‐aminoethyl) propane haxaacetic acid labeled with technitium‐99m
Author(s) -
Wang R. F.,
Zhang C. L.,
Huo L.,
He X. K.,
Fu Z. L.,
Liu G. Z.,
Liu F.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401223
Subject(s) - chemistry , excretion , probenecid , kidney , renal function , urine , renal physiology , medicine , biochemistry
The purpose of this study is to prepare 99m Tc‐diaminoethylpropane diamine haxaacetic acid and clarify its renal excretion mechanism. BPHA obtained from chemical synthesis and characterized by IR and MS was labeled with technitium‐99m. The renal excretion mechanism was determined by probenecid inhibition experiment. The radioactivity remained in the body at different time point postinjection was measured by a γ detector. Renal dynamic imaging of rabbit and human was performed using a γ camera. For all the experiments 99m Tc‐DTPA was also examined as contrast. Similar to 99m Tc‐DTPA, 99m Tc‐BPHA was excreted with a glomerular excretion mechanism. After 24 h, 99m Tc‐BPHA remained in the body was very little. Kidney imaging of rabbit and volunteer showed excellent kidney images and fast 99m Tc‐BPHA excretion. The results showed that the self‐made 99m Tc‐BPHA appeared to be a glomerular filtration imaging agent satisfying clinical requirement and an alternative to 99m Tc‐DTPA.