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Synthesis and characterization of [ 99m Tc]metomidate as the tricarbonyl‐conjugate
Author(s) -
Netter M.,
Zolle I.,
Schibli R.,
Hammerschmidt F.,
Berger M.,
Schubiger P. A.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401221
Subject(s) - conjugate , chemistry , yield (engineering) , ligand (biochemistry) , in vivo , stereochemistry , biochemistry , mathematical analysis , materials science , receptor , mathematics , microbiology and biotechnology , metallurgy , biology
Functionalized metomidate was labelled with the [ 99m Tc]tricarbonyl‐complex in high yield. With carrier amounts of Tc‐99 the analogous [ 99 Tc]tricarbonyl‐BiPy‐MTO‐conjugate was obtained, showing an identical retention time, however, conjugate formation was not quantitative. When the [Re]tribromo‐tricarbonyl‐ligand was reacted with the BiPy‐MTO‐precursor, the reaction parameters had to be optimized for conjugate formation. Based on high adrenocortical binding to adrenal tissue slices, it is expected that the radiotracer will also localize in the adrenal in‐vivo.