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Cyclopentadienyl tricarbonyl technetium‐99m octanoic acid: A novel radiotracer for evaluation of fatty acid metabolism in the liver
Author(s) -
Lee B. C.,
Choe Y. S.,
Lee K.H.,
Chi D. Y.,
Kim S. E.,
Choi Y.,
Kim B.T.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401190
Subject(s) - chemistry , metabolism , radiochemistry , technetium , cyclopentadienyl complex , fatty acid , fatty acid metabolism , solubility , yield (engineering) , biochemistry , nuclear chemistry , organic chemistry , catalysis , materials science , metallurgy
Cyclopentadienyl tricarbonyl 99m Tc octanoic acid ( 99m Tc‐CpTOA; 1) was prepared in high radiochemical yield (40–63%) and shown to be stable (90% at 6 h) in human serum. Biological studies demonstrated longer retention and slower metabolism of 99m Tc‐CpTOA in CCl 4 ‐treated mice than in normal mice, possibly due to impaired β‐oxidation. These results along with good water solubility of the radioactive extracts from the liver indicated that this radiotracer was mainly metabolized via β‐oxidation in the liver. This study thus suggests that 99m Tc‐CpTOA 1 holds promise for evaluation of fatty acid metabolism in the liver.