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Tc Oxocomplexes with the PNO/S and PNS/S donor atom sets: Labelling of a 5HT 1A receptor — binding ligand
Author(s) -
Fernandes C.,
Correia J. D. G.,
Gano L.,
Santos I.,
Seifert S.,
Syhre R.,
Spies H.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401184
Subject(s) - chemistry , piperazine , labelling , ligand (biochemistry) , biodistribution , chelation , aqueous solution , receptor , high performance liquid chromatography , stereochemistry , organic chemistry , in vitro , biochemistry
Mixed — ligand model complexes, [ 99m Tc(O)(PNX)(SPh)] (XO (1a), S (2a)), were synthesized from [ 99m TcO 4 ] − . These compounds were characterized by comparing their radioactive HPLC profiles with the UV profiles of the analytically pure Re compounds 1 and 2. Based on stability studies, undertaken in aqueous solutions and in glutathione challenge experiments, 2a was chosen for biodistribution studies in rats. Using this approach, the labelling of a 5‐HT 1A receptor ligand (derivatized aryl‐piperazine) with 99m Tc was also performed using the PNS chelate.