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The mixed ligand [2+1] approach: An easier way of labeling the [M(CO) 3 ] + core (M= 99,99M TC, RE)?
Author(s) -
Ortner K.,
Kündig M.,
Mundwiler S.,
Alberto R.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401179
Subject(s) - denticity , chemistry , ligand (biochemistry) , chelation , biomolecule , metal , stereochemistry , crystallography , crystal structure , inorganic chemistry , receptor , organic chemistry , biochemistry
Within the mixed ligand [2+1] approach several model complexes of the general formula [ 99m Tc(OH 2 )(L∩L)(CO) 3 ] have been synthesized in one step starting from [TcO 4 ] − . Only one bidentate ligand co‐ordinates to the metal centre allowing the co‐ordination of a monodentate ligand which can easily be connected to a biomolecule. Our labeling experiments of peptides bound to a monodentate ligand show that the [2+1] approach is possibly too slow for a radiopharmaceutical application. A similar approach with the biomolecule bound to a bidentate chelator overcomes these disadvantages but retains advantages of the mixed ligand concept.