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Vincristine toxicity: The effect on the biodistribution of radiopharma ceutical and in the optical microscopy of organs isolated from the treated animals
Author(s) -
Mattos D. M. M.,
Gomes M. L.,
Freitas R. S.,
Moreno S.,
Nascimento A. L. R.,
Carvalho J. J.,
BernardoFilho M.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401169
Subject(s) - biodistribution , spleen , chemistry , kidney , toxicity , stomach , vincristine , pharmacology , lymph , pathology , medicine , chemotherapy , biochemistry , organic chemistry , in vitro , cyclophosphamide
There are many articles and textbooks quoting examples of drug‐radiopharmaceutical interactions. Such interactions arise as a result of an exaggerated pharmacological activity of the drug producing altered biodistribution of the radiopharmaceutical. Vincristine was administered into mice, one hour after the last dose, technetium‐99m‐diethylenetriaminepentaacetic acid ( 99m Tc‐DTPA) was injected. After 0.5 hour, the animals were sacrificed and the percentage of total radioactivity (%ATI) was calculated. In the treated animals, 99m Tc‐DTPA has increased in uterus, ovary, spleen, thymus, lymph nodes, kidney, lung, liver, stomach, heart and bone. Optical microscopy of a portion of ring fragment of spleen, kidney and liver were cut into strips and fixed, postfixed, dehydrated and Epon embedded. Semithin sections were prepared and stained with toluidine blue. The results revel that in kidney and liver no have alterations, but, in spleen, an increased of extracellular matrix was observed. The results can be explained by its metabolization, therapeutic, toxic and/or immunosupressive actions of this chemotherapeutic drug.