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Synthesis of [ 18 F]‐Fluoroethylfenoterol for imaging β2 receptor status in lung in vivo
Author(s) -
Schirrmacher E.,
Schirrmacher R.,
Buhl R.,
Wessler I.,
Machulla H.J.,
Rösch F.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401154
Subject(s) - chemistry , in vivo , fenoterol , benzene , stereochemistry , in vitro , medicinal chemistry , organic chemistry , biochemistry , medicine , microbiology and biotechnology , asthma , biology
5‐(‐{2‐[4‐(2‐[ 18 F]Fluoroethoxy)‐phenyl]‐l‐methyl‐ethylamino}‐l‐hydroxy‐ethyl)‐benzene‐1, 3‐diol ([ 18 F]fluoroethylfenoterol) was synthesised from 4‐(2‐{benzyl‐[2‐(3,5‐bis‐benzyloxy‐phenyl)‐2‐hydroxy‐ethyl]‐amino}‐propyl)‐phenol using 2‐[ 18 F]fluoroethyltosylate (92% RCY) followed by reductive cleavage of the benzyl protecting groups. Preliminary in vitro tests showed [ 19 F]fluoroethylfenoterol to be as potent in relaxation of lung tissue as fenoterol itself.