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Halogen‐substituted triarylpyrazoles: Potential estrogen receptor‐alpha selective radiopharmaceuticals
Author(s) -
Vijaykumar Dange,
Katzenellenbogen John A.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401120
Subject(s) - chemistry , estrogen receptor , estrogen receptor beta , alpha (finance) , beta (programming language) , ligand (biochemistry) , estrogen , estrogen receptor alpha , halogen , receptor , estrogen related receptor alpha , stereochemistry , biochemistry , medicine , organic chemistry , cancer , nursing , alkyl , construct validity , breast cancer , computer science , patient satisfaction , programming language
Halogen‐substituted analogs of a pyrazole ligand for the estrogen receptor have been synthesized. These analogs retain much of the affinity preference of the parent ligand for the estrogen receptor alpha subtype (ERα) vs the beta subtype (ERβ).