Premium
Preparation of [ 124 I]IBA‐annexin‐V as a potential pet probe for apoptosis
Author(s) -
Glaser M.,
Collingridge D. R.,
Aboagye E.,
BouchierHayes L.,
Brown D. J.,
Hutchinson O. C.,
Martin S.,
Price P.,
Luthra S. K.,
Brady F.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401118
Subject(s) - annexin , chemistry , apoptosis , in vitro , annexin a2 , annexin a5 , microbiology and biotechnology , biochemistry , biology
[ 124 I]Iodo‐annexin‐V and [ 124 I]IBA‐Annexin‐V have been prepared using direct and indirect methods, respectively. [ 124 I]IBA‐annexin‐V was prepared using [ 124 I] m ‐ N ‐succinimidyl iodobenzoate ([ 124 I] m ‐SIB). Preliminary in vitro binding studies have shown enhanced binding of [ 124 I]IBA‐annexin‐V to human leukaemic cells induced to undergo apoptosis compared to untreated cells.