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A reinvestigation of the synthesis of [ 15 N 2 ]hydroxymethylimidazole: Useful in an improved synthesis of (D,L)‐[τ,π‐ 15 N 2 ]histidine
Author(s) -
Silks Louis A.,
Dunkle Erik,
Ünkefer Clifford J.,
Sudmeier James L.,
Butler Michael,
Bachovchin William W.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580361006
Subject(s) - chemistry , imidazole , dihydroxyacetone , histidine , hydroxymethyl , yield (engineering) , picric acid , formaldehyde , ammonia , organic chemistry , combinatorial chemistry , medicinal chemistry , enzyme , materials science , glycerol , metallurgy
We have reinvestigated the synthesis of [ 15 N 2 ]hydroxymethyl imidazole from dihydroxyacetone, formaldehyde, and labelled ammonia in an attempt to optimize the yield from the isotope. Conversion of the hydroxymethyl imidazole to histidine was accomplished in good yield without the need for picric acid as an ion pairing agent.