Premium
Synthesis of [ 14 C]KT3‐671, 2‐Propyl‐8‐oxo‐1‐[ (2′‐(1H‐[ 14 C] tetrazole‐5‐yl) biphenyl‐4‐yl) methyl]‐4,5,6, 7‐tetrahydro‐cycloheptimidazole, a novel potent nonpeptide angiotensin II receptor antagonist
Author(s) -
Ueyama Naoto,
Yanagisawa Takashi,
Tomiyama Tsuyoshi
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580361002
Subject(s) - chemistry , tetrazole , biphenyl , potassium cyanide , chemical synthesis , cyanide , yield (engineering) , imidazole , potassium , medicinal chemistry , stereochemistry , organic chemistry , in vitro , biochemistry , materials science , metallurgy
2‐Propyl‐8‐oxo‐1‐[(2′‐(1H‐tetrazole‐5‐yl) biphenyl‐4‐yl)methyl]‐4, 5, 6, 7‐tetrahydrocyclohept imidazole (KT3‐671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in 14 C‐labelled form by using potassium[ 14 C]‐cyanide. [ 14 C](KT3‐671) 9 with a specific activity of 1.74GBq/mmol was prepared in four steps in 29.8% overall radio‐chemical yield from potassium[ 14 C]‐cyanide.