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Carbon‐14 labelled nitrogen heterocycles; the syntheses of three phosphodiesterase inhibitors
Author(s) -
Lawrie Kenneth W M,
Novelli Christine E A,
Saunders David,
Coates William J
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360910
Subject(s) - chemistry , amidine , nitrile , ketone , ring (chemistry) , phosphodiesterase , chemical synthesis , stereochemistry , organic chemistry , enzyme , biochemistry , in vitro
The syntheses of three heterocyclic phosphodiesterase inhibitors are described from a common radiolabelled precursor, namely 2‐propoxybenzo[ cyano ‐ 14 C]nitrile. Conversion of the nitrile to the corresponding methyl ketone or amidine allows elaboration of the heterocycles radiolabelled within the ring systems.