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Synthesis of a tritium labeled rat enterostatin, Val‐[3,4‐ 3 H‐Pro]‐Gly‐[3,4‐ 3 H‐Pro]‐Arg‐Oh
Author(s) -
Kozlowski Edward S.,
Dischino Douglas D.,
Johnson Graham
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360908
Subject(s) - chemistry , tritium , tritium illumination , methanol , specific activity , catalysis , radiochemistry , medicinal chemistry , organic chemistry , enzyme , physics , nuclear physics
A tritium labeled rat Enterostatin, Val‐[3,4‐ 3 H‐Pro]‐Gly‐[3,4‐ 3 H‐Pro]‐Arg‐OH, was prepared by the catalytic tritiation of the didehydroproline analog of rat Enterostatin, Val‐[3,4‐dehydroPro]‐Gly‐[3,4‐dehydroPro]‐Arg‐OH, over Pd/C in methanol. The product had a specific activity of 59.2 Ci/mmol and a radiochemical purity of greater than 99%.