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Synthesis of H‐3 labeled 5‐fluoro‐3‐[3‐[4‐(5‐methoxy‐4‐pyrimidinyl)‐1‐piperazinyl]propyl]‐1H‐indole, a serotonergic agent with potential antidepressant activity
Author(s) -
Dischino Douglas D.,
Combrink Keith D.,
Doweykos Lidia,
Morimoto Hiromi,
Pearce Bradley C.,
Williams Philip G.,
Yevich Joseph P.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360810
Subject(s) - chemistry , serotonergic , indole test , stereochemistry , high performance liquid chromatography , serotonin , pharmacology , chromatography , biochemistry , receptor , medicine
The title compound was prepared by the LiAlT 4 reduction of 5‐fluoro‐3‐[3‐[4‐(5‐methoxy‐4‐pyrimidinyl)‐1‐piperazinyl]‐3‐oxopropyl]‐1H‐indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol from HPLC analyses and 55.6 Ci/mmol from 3 H NMR measurements.