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Preparation and investigation of [ 14 C]padimate‐O and [ 14 C]N‐nitroso‐N‐nor‐padimate‐O
Author(s) -
Lewin Anita H.,
Fudala Louise
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360705
Subject(s) - chemistry , nitrosation , carbonation , medicinal chemistry , bromobenzene , nitroso , sodium nitrite , nitroso compounds , decomposition , nuclear chemistry , carbon 14 , lithium (medication) , organic chemistry , catalysis , medicine , physics , quantum mechanics , endocrinology
Carbonation of the aryl lithium obtained from p‐N,N(dimethylamino)bromobenzene with carbon‐14 labeled carbon dioxide, followed by esterification gave [CO 2 ‐ 14 C]p‐N,N(dimethylamino)benzoate 2‐ethylhexyl ester (Padimate‐O). This material underwent slow decomposition to [ 14 C]N‐nor‐Padimate‐O and [ 14 C]N‐formyl‐N‐nor‐Padimate‐O. Nitrosation of [ 14 C]Padimate‐O with sodium nitrite afforded [ 14 C]N‐nitroso‐N‐nor‐Padimate‐O.