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Synthesis of [ 14 C 2 ] SDZ FOX 988, a hypoglycemic agent
Author(s) -
Sunay Ustun B.,
Talbot Kenrick,
Prasad Kapa,
Lee George,
Jones Lawrence
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360604
Subject(s) - chemistry , benzoic acid , condensation , carbon 14 , medicinal chemistry , stereochemistry , organic chemistry , physics , thermodynamics , quantum mechanics
4‐[2,2‐Dimethyl‐1‐oxopropyl‐1‐[ 14 C]‐4‐[2,2‐dimethyl‐1‐oxopropyl‐ 1‐[ 14 C]‐phenyl(methoxyimino)‐benzoic acid, methyl ester, [ 14 C 2 ] SDZ FOX 988, doubly labelled in the two keto carbons, was prepared from 4‐bromotoluene in four steps. The final condensation featured a novel method for preparation of N‐oxyimidic acid derivatives.