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Synthesis of carbon‐11 labeled methylcarbamates from [ 11 C]‐methylchloroformate
Author(s) -
Ravert Hayden T.,
Mathews William B.,
Musachio John L.,
Dannals Robert F.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360409
Subject(s) - chemistry , yield (engineering) , reagent , methanol , phosgene , carbon 14 , specific activity , primary (astronomy) , carbon fibers , radiochemistry , organic chemistry , medicinal chemistry , nuclear chemistry , materials science , physics , quantum mechanics , astronomy , composite number , metallurgy , composite material , enzyme
[ 11 C]‐Methylchloroformate, a novel [ 11 C]‐acylating agent, was generated in situ from [ 11 C]‐methanol and phosgene. To explore the utility of [ 11 C]‐methylchloroformate, this agent was reacted with several amines to yield their corresponding [ 11 C]‐labeled methylcarbamates. The average synthesis (including purification and formulation) required approximately 23 minutes from end of bombardment. The average specific activity was calculated to be approx. 607 mCi/μmole at end of synthesis with an average radiochemical yield of 6%, decay corrected to starting [ 11 C]‐methanol. Preliminary results reveal that [ 11 C]‐methylchloroformate is a useful general reagent for the preparation of [ 11 C]‐methyl carbamates of both primary and secondary amines.