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Preparation of n ‐butoxy( 13 C 2 ‐acetic) acid, 1‐ n ‐butoxy‐2‐hydroxy ( 13 C 2 ‐ethane), ( n ‐butoxy‐2′,2′,3′,3′,4′,4′,4′‐ d 7 )acetic acid, and 2‐( n ‐butoxy‐2′,2′,3′,3′,4′,4′,4′‐ d 7 )ethanol
Author(s) -
Pribish James R.
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360304
Subject(s) - chemistry , acetic acid , yield (engineering) , ethanol , medicinal chemistry , carbon 13 , nuclear chemistry , organic chemistry , materials science , metallurgy , physics , quantum mechanics
( n ‐Butoxy‐2′,2′,3′,3′,4′,4′,4′‐ d 7 )acetic acid ( 1 ) and 2‐( n ‐butoxy‐2′,2′,3′,3′,4′,4′,4′‐ d 7 )ethanol ( 2 ) have been prepared in high yield from n ‐butanol‐2,2,3,3,4,4,4‐ d 7 . n ‐ Butoxy( 13 C 2 ‐acetic) acid ( 3 ) and 1‐ n ‐butoxy‐2‐hydroxy( 13 C 2 ‐ethane) ( 4 ) have also been synthesized using bromoacetic‐ 13 C 2 acid as the source of labelled carbon. The main complication in the development of the process was partial conversion of butoxyacetic acid to butyl butoxyacetate during GC analysis, which hampered evaluation of trial reactions.