Premium
New [ 99m Tc]‐cytectrene amine compounds as specific brain imaging agents
Author(s) -
Kuntschke Dirk,
Wenzel Martin,
Schulze Paul
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360212
Subject(s) - chemistry , biodistribution , technetium 99m , tertiary amine , hydrolysis , amine gas treating , metabolite , technetium , radiochemistry , imaging agent , yield (engineering) , nuclear chemistry , organic chemistry , in vivo , nuclear medicine , biochemistry , scintigraphy , in vitro , materials science , microbiology and biotechnology , medicine , biology , metallurgy
Lipophilic tertiary amines attached to cyclopentadienyl technetium‐99m tricarbonyl (cytectrene) have been prepared with high radiochemical yield and purity. Biodistribution studies in mice showed that [ 99m Tc]‐cytectrenes, containing in their structure an N‐methylpiperidine, were accumulated in the brain up to 2.8 % of injected dose with high brain‐to‐blood ratios at 15 min p.i. 1 . They therefore indicate some potential as brain imaging agents. It has to be pointed out that the N‐methylpiperidine ester showed similar biological behaviour as the keto derivative. This indicates that the conversion to polar metabolite(s) via hydrolysis of the ester group ‐ as described for [ 99m Tc]‐ECD ‐ is not essential for brain retention.