Premium
Synthesis of (+)‐(3R)‐3‐(4‐fluorophenylsulfonamido)‐1,2,3,4‐tetrahydro‐9‐[5,6,7,8,12,13‐U‐ 14 C]carbazolepropanoic acid, [ 14 C]BAY u 3405
Author(s) -
Radtke Martin,
Boberg Michael,
Pleiss Ulrich,
Rosentreter Ulrich
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580341210
Subject(s) - chemistry , aniline , yield (engineering) , chemical synthesis , stereochemistry , radiochemistry , medicinal chemistry , nuclear chemistry , organic chemistry , physics , biochemistry , thermodynamics , in vitro
The title compound [ 14 C]BAY u 3405 ( 1 ) was synthesized as part of 8‐step sequence. Starting from [U‐ 14 C]aniline hydrogensulfate the final product 1 was obtained with a specific activity of 741 MBq/mmol (20 mCi/mmol) and a radiochemical purity of > 98% in an overall yield of 6 and 10% depending on the method.