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New processes for the synthesis of 2,6‐dichloro‐3‐methylaniline‐Ph‐UL‐ 14 C and methyl 6‐chloroanthranilate‐Ph‐UL‐ 14 C
Author(s) -
McKendry L. H.,
Stanga M. A.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580341205
Subject(s) - chemistry , chemical synthesis , product (mathematics) , biochemistry , in vitro , geometry , mathematics
Two new processes were developed for the synthesis of 2,6‐dichloro‐3‐methylaniline‐Ph‐UL‐ 14 C (1), a key intermediate in the synthesis of a Dow Elanco experimental product presently being considered for commercialization. Both processes afford product in much higher yields than that previously reported in the literature. One of the processes was subsequently applied to the synthesis of methyl 6‐chloroanthranilate‐Ph‐UL‐ 14 C ( 12 ), used as an intermediate for a second potential product.