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Labelling of benzocaina with tritium
Author(s) -
Malik Sohail
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580341013
Subject(s) - tritium , chemistry , benzocaine , labelling , sodium borohydride , radiochemistry , tritium illumination , nuclear chemistry , hydrogen , catalysis , organic chemistry , biochemistry , biology , physics , nuclear physics , immunology
Abstract A convenient method is described to label a local anesthetic, benzocaine, with tritium. The bromoester of para — aminobenzoic acid (PABA) was prepared from para ‐nitrotoluene and was reduced with tritium. The generation of isotopic hydrogen and labelling of benzocaine was achieved in one‐step. A mixture of sodium borohydride (NaB 3 H 4 ) with cobalt (II) chloride was used to generate tritium gas. 5% Pd/C was used as a catalyst. This constitutes the first report of tritium labelled benzocaine.