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The synthesis of (−)‐4‐methyl‐8‐chloro‐ trans ‐1,2,3,4,4a,5,6,10b‐octahydrobenzo‐[f]‐quinolin‐3‐one‐[3‐ 14 C] (LY300502‐ 14C ]) via a circuitous route
Author(s) -
Kuo Fengjiun,
Wheeler William J.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580341004
Subject(s) - chemistry , isotopomers , stereochemistry , bicyclic molecule , combinatorial chemistry , organic chemistry , molecule
The synthesis of the C‐14 labeled isotopomer of LY300502, a potent 5α‐reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502‐[ 14 C] from LY300502 via a circuitous route; the label was introduced with ethyl chloroformate‐[carbonyl‐ 14 C].