The synthesis of (−)‐4‐methyl‐8‐chloro‐ trans ‐1,2,3,4,4a,5,6,10b‐octahydrobenzo‐[f]‐quinolin‐3‐one‐[3‐ 14 C] (LY300502‐ 14C ]) via a circuitous route

The synthesis of the C‐14 labeled isotopomer of LY300502, a potent 5α‐reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502‐[ 14 C] from LY300502 via a circuitous route; the label was introduced with ethyl chloroformate‐[carbonyl‐ 14 C].