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A convenient method for cyanation of aromatic iodo compounds
Author(s) -
Carr Richard M,
Cable Karl M,
Wells Guy N,
Sutherland Derek R
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340910
Subject(s) - chemistry , cyanation , combinatorial chemistry , organic chemistry , catalysis
A variety of [ 13 C]‐labelled aromatic nitriles have been prepared in good yield from iodoaromatic substrates. Cyanation was achieved by reaction of aryl iodides with a mixture of potassium [ 13 C]‐cyanide and copper (I) iodide in an aprotic solvent at high temperature. The use of pre‐prepared carbon‐labelled copper (I) cyanide was therefore obviated.