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Tritiation of organic compounds by polymer‐supported base catalysts
Author(s) -
Brewer J. R.,
Jones J. R.,
Lawrie K. W. M.,
Saunders D.,
Simmonds A.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340812
Subject(s) - chemistry , catalysis , pyridinium , ion exchange , polymer , ion exchange resin , organic base , thermal stability , base (topology) , hydrogen , salt (chemistry) , tritium , inorganic chemistry , organic chemistry , polymer chemistry , ion , mathematical analysis , mathematics , physics , nuclear physics
A range of organic compounds have been tritiated (and in some cases deuteriated) via hydrogen isotope exchange reactions using polymer supported base catalysts. The problem of poor thermal stability of some commercially available anion exchange resins, which limits their use as tritiation catalysts, has been overcome by the preparation of a more stable polymer supported pyridinium salt. The anion exchange resins are as effective at very high activities of tritiated water as they are at low and compounds containing nitro groups, which poison metal‐catalysed exchange reactions, can be successfully labelled.