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Synthesis of isotopically‐labelled nitroxyl radicals for use as spin probes
Author(s) -
Bolton Roger,
Sutcliffe Leslie H.,
Wu Xiaoping
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340711
Subject(s) - chemistry , lipophilicity , nitroxyl , alkyl , radical , deuterium , nitrogen , organic chemistry , combinatorial chemistry , physics , quantum mechanics
The synthesis of [ 15 N]‐1,1,3,3‐tetrakis(trideuteriomethyl)isoindolin‐2‐yloxyl and of some 5‐alkyl derivatives have been achieved by standard synthetic routes. 1 The presence of deuterium improves the sharpness of the signals, and this, together with the incorporation of nitrogen‐15, enhances the application of such compounds as spin probes; alkyl substituents at C‐5 improve the lipophilicity.