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Preparation of high molecular weight radioiodinated alginic acid
Author(s) -
Orlando P.,
Binaglia L.,
De Feo A.,
Trevisi R.,
Melodia C.,
Trenta R.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340709
Subject(s) - alginic acid , chemistry , sodium cyanoborohydride , chromatography , organic chemistry , biochemistry
A simple procedure is described for preparing 125 I‐labelled alginic acid. The reducing terminal of alginic acid is derivatized with tyramine through the formation of Schiff base which is subsequently reduced with sodium cyanoborohydride. By radioiodination of the aromatic ring introduced, 125 I‐labelled alginic acid was obtained with high specific activity.