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Complexation behaviour of tin(II) ion with derivative of p‐aminohippuric acid
Author(s) -
Djurdjevic Predrag,
Maksin Tatjana,
Veselinovic Dragan
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340511
Subject(s) - chemistry , potentiometric titration , tin , yield (engineering) , inorganic chemistry , hippuric acid , ion , stability constants of complexes , electroanalytical method , hydrolysis , ionic bonding , nuclear chemistry , organic chemistry , urine , biochemistry , materials science , metallurgy
Complex formation between tin(II) ion and p‐(biscarboxymethyl)‐aminomethyl‐carbamino‐hippuric acid (PAHIDA) in 0.5 M NaClO 4 ionic medium at 298 K, was studied by means of u.v. spectrophotometry and glass electrode potentiometric titrations. In the concentration range 0.09 ⩽ [Sn] ⩽ 0.150, 0.5 ⩽ [PAHIDA] ⩽ 3.0 (mmol dm −3 ) and 1.30 ⩽ pH ⩽ 6.5, mathematical analysis of potentiometric data, with the aid of general least‐squares programme Superquad, indicates the formation of the following complexes and their respective stability constants (log (β ± σ)): [Sn(H 2 PAHIDA)] (12.98 ± 0.15), [Sn(HPAHIDA)] (9.38 ± 0.05), [Sn(PAHIDA)] (5.74 ± 0.01) and [Sn(OH)PAHIDA] (1.55 ± 0.09) as well as several pure hydrolytic complexes of tin(II). The effect of tin(II)‐PAHIDA complexation on labelling yield of PAHIDA with 99m TcO 4 − was investigated. The optimum yield (90%) was achieved at PAHIDA to tin(II) concentration ratio 30:1 and pH = 5.5.
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