Premium
A novel one step approach to small scale labeling of organic compounds with hydrogen isotopes
Author(s) -
Malik Sohail,
Kenny Margaret,
Doss George,
John Varghese
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340510
Subject(s) - chemistry , sodium borohydride , tritium , hydrogen , hydrogen chloride , tritium illumination , radiochemistry , isotope , hydrogen isotope , inorganic chemistry , combinatorial chemistry , organic chemistry , catalysis , nuclear physics , physics
A rapid method to generate tritium gas for small scale labeling is described. Tritium labelled sodium borohydride is used with cobalt (II) chloride to generate isotopic hydrogen gas. The reaction was carried out in a closed vessel and three different compounds were concurrently labelled. This simple and inexpensive method can be applied to a broad range of molecules and does not require any special set up.