Premium
Tritiation of organic compounds by polymer‐supported acid catalysts
Author(s) -
Brewer J. R.,
Jones J. R.,
Lawrie K. W. M.,
Saunders D.,
Simmonds A.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340411
Subject(s) - chemistry , catalysis , polymer , hydrogen , hydrogen isotope , substrate (aquarium) , organic chemistry , tritium , organic polymer , inorganic chemistry , oceanography , physics , nuclear physics , geology
A range of organic compounds have been tritiated (and in some cases deuteriated) via hydrogen isotope exchange reactions using polymer supported acid catalysts. The extent and regiospecificity of labeling were investigated as a function of substrate and catalyst type. Although all the catalysts were found to be active in the tritiation of both aromatic and heterocyclic compounds, there was clear evidence that the extent of hydrogen isotope exchange was influenced by the nature of the polymer support matrix.