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Synthesis of 4‐stannylated tamoxifen analogues; useful precursors to radiolabelled idoxifene and aziridinyl 4‐iodotamoxifen
Author(s) -
McCague Raymond,
Potter Gerard A.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340313
Subject(s) - chemistry , tamoxifen , alkoxy group , stereochemistry , breast cancer , organic chemistry , cancer , medicine , alkyl
The 4‐stannylated tamoxifen analogues ( E )‐1‐[4‐[2‐( N ‐pyrrolidino)ethoxy]phenyl]‐1‐[4‐(tributylstannyl)phenyl]‐2‐phenyl‐1‐butene and ( E )1‐[4‐[2‐(aziridin‐1‐yl)ethoxy]phenyI]‐1‐[4‐(tributylstannyl)phenyl]‐2‐phenyl‐1‐butene have been synthesised as precursors to radiolabelled idoxifene, an important new drug for the treatment of breast cancer, and to aziridinyl 4‐iodotamoxifen, a potentially useful biological research tool for studying the action of tamoxifen, respectively.