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Synthesis and purification of desmethylzopiclone‐N‐{3‐(4‐hydroxy‐3‐[ 125 I]‐iodophenyl) propionamide}, a prosthetic derivative of zopiclone for use in immunoassay
Author(s) -
Mannaert E.,
Daenens P.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340311
Subject(s) - chemistry , reagent , derivative (finance) , high performance liquid chromatography , chromatography , immunoassay , tracer , stereochemistry , medicinal chemistry , organic chemistry , antibody , physics , nuclear physics , financial economics , immunology , economics , biology
Condensation of [ 125 I]‐Bolton/Hunter reagent with N‐desmethylzopiclone lead to the title compound which was isolated and purified by normal phase HPLC, in combination with gamma counting detection. The introduction of the prosthetic group into the tracer precursor was proven by L‐SIMS.