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The synthesis of 6,6,6‐ 2 H 3 ‐2E‐hexenal
Author(s) -
Fielder Simon,
Rowan Daryl D.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340214
Subject(s) - chemistry , aldehyde , yield (engineering) , bromide , magnesium bromide , organic chemistry , magnesium , in situ , catalysis , materials science , metallurgy
6,6,6‐ 2 H 3 ‐2E‐Hexenal, leaf‐aldehyde, has been synthesized in 45% yield and 99.3% purity by reaction of 3,3,3‐ 2 H 3 ‐ n ‐propyl magnesium bromide with an ethereal solution of 3‐trimethylsiloxy‐2‐propenal (3) prepared in situ . This new one pot procedure alleviates the need to isolate (3) and should prove useful in the synthesis of other E‐α,β‐unsaturated aldehydes.