Premium
Synthesis of 14 C‐labeled copolymers for drug delivery studies
Author(s) -
Rhee Sung W.,
Reist Elmer J.,
Rock Marie T.
Publication year - 1994
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580340210
Subject(s) - sebacic acid , chemistry , copolymer , gel permeation chromatography , acetic anhydride , propane , acetic acid , polymer chemistry , nuclear chemistry , organic chemistry , catalysis , polymer
14 C‐labeled polyanhydride copolymers [(20:80/1,3‐bis)(p‐carboxyphenoxy)‐propane(CPP):sebacic acid (SA)] ( 7 and 13 ) were synthesized according to schemes I and II: 14 C‐labeled sebacic acid (2,9‐ 14 C 2 ) (5) and 14 C‐labeled CPP 1,3‐bis(p‐carboxyphenoxy)‐propane (labeled at C‐1, C‐3 of the propyl group) ( 11 ) were transformed to the corresponding mixed anhydrides ( 6 and 12 ) as prepolymers respectively by reaction with acetic anhydride. The labeled mixed anhydride prepolymers ( 6 and 12 ) were condensed with unlabeled counter‐prepolymers (12′ and 6′) to give the labeled polyanhydride copolymers ( 7 and 13 ). The labeled copolymers ( 7 and 13 ) were identified and characterized by gel permeation chromatography (GPC).